Tylenol 3’s not good for breastfeeding moms
Saturday, August 23rd, 2008I am always very cautious when I am prescribed medications as a breastfeeding mother because you just never know. But with every illness and treatment, you must weigh the pros and cons before making a decision, just make sure you have all the information. Considering the widespread use of Tylenol 3’s, I thought this article posted by the London Free Press needed to be passed on. It is also copied entirely below, you know, just in case.
Breastfed babies at risk
Thurs, August 21, 2008
Some moms may pass morphine on to baby
A University of Western Ontario medical professor investigating the morphine overdose death of a baby is urging doctors to reconsider the widespread practice of prescribing Tylenol 3 painkillers to new mothers.
Dr. Gideon Koren and fellow researchers found the codeine in Tylenol 3 can be transformed by some women’s bodies into dangerous levels of morphine in their breast milk.
“To the medical community, we should rethink carefully if we are not overusing this medication,” said Koren, the Richard and Jean Ivey Chair in molecular toxicology at the Schulich School of Medicine and founder and director of the Motherisk Program at the University of Toronto.
In addition to the baby who died, the researchers found another baby who had been close to death because of high morphine levels and others who showed signs of central nervous system depression.
The babies’ mothers had a genetic variation found in about one per cent of Caucasian women, but in as many as 30 per cent of Ethiopians.
“In a place like Ontario where you have people from over 200 countries, you can’t really predict who will have it,” Koren said.
The research results are published in Nature’s Clinical Pharmacology Journal.
It’s estimated Tylenol 3 is prescribed to 40 per cent of breastfeeding mothers in North America, mainly women who have had a caesarean section or episiotomy.
The researchers found that babies are much more sensitive to the morphine from codeine than adults.
Koren said that’s probably because the blood-brain barrier is not as developed in infants.
The effect of the central nervous depression on the babies studied included drowsiness and sleeping more than normal.
Mothers often wouldn’t be able to wake them for feeding.
“The important point in all cases is once mom either stopped the codeine or stopped the breastfeeding, the baby was a new baby,” Koren said.
Detecting that a baby is sleeping too much is difficult for new parents who have no experience to measure it against, he said.
“Babies don’t tell us, they don’t speak to us, new parents will not know. It’s a very tricky situation.”
In most cases where the baby was sleeping too much, the mother also had signs of grogginess.
“If mom begins to feel she is not OK, think about the baby because the baby may not tell you about it,” he said.
If the mother has side effects from the codeine, the baby needs to be seen by a physician, Koren said.
He also recommends that breastfeeding women prescribed Tylenol 3 take the minimal amount needed to control their pain.
During their study, the scientists found one baby with central nervous system depression whose mother had only taken one and half Tylenol 3s.
Mothers should try not to use codeine for more than four days, Koren said.
The scientists found that babies who were affected were ones where the mothers had taken codeine for seven, eight or nine days.
European and other developed countries do not prescribe Tylenol 3 to new mothers, mainly to avoid the side effect of constipation.
Studies, including a Canadian one, have found other drugs are just as effective at controlling pain, Koren said.
But it may be a hard sell to convince physicians used to prescribing Tylenol 3 to switch to something else, he said.
“It won’t be easy because T3s are like Frigidaire . . . it is one of the things that North America is very used to, and generations of physicians are used to, but they may need to rethink it.”




